作者： admin

　　Zhongxin. com, Kashgar, Xinjiang, June 3 (Reporter Zhu Jingchao) The reporter learned from the China Merchants Bureau in Kashgar, Xinjiang on the 3 rd that the high-spicy peppers implemented by aid enterprises Shenzhen and Zhengyuan Technology Group were successfully planted in Kashgar and other places. This year, they have been planted in a large area and industrialized to help the local consolidate the results of poverty alleviation.

　　On the 3rd, the reporter saw in Jiashi County, Kashgar, a thousand acres of high-spicy pepper planting base that it was growing well. He Ming, the first secretary of the Gezikushan River Basin Management Office in Kashgar who was stationed in Qirike Village, Jiashi County, and the leader of the visiting team, told the reporter that the high-spicy pepper project was introduced by the village committee in contact with the Shenzhen Chamber of Commerce. In the Xinmei nursery base of the village, Shenzhen Hezhengyuan Science and Technology Group provided high-spicy pepper seedlings and technical management free of charge, and the village cooperative transferred 128 farmers’ land at a transfer fee of 600 yuan per mu. At present, there are 60 laborers working in the field. At the autumn harvest, the group is responsible for the acquisition.

　　Chen Haiou, chairman of Shenzhen Hezhengyuan Science and Technology Group, said that in 2020, the trial planting of high-spicy peppers was successful in southern Xinjiang. According to the test report of Chengdu Huace Testing Technology Co., Ltd., the capsaicin content reached the standard and other indicators were excellent. This year, it has been planted in Kashgar, Hotan and other counties and cities, reaching 10,000 mu.

　　He said that the peppers planted this year are mainly used for the production of hot pot bottom materials and seasonings. At the same time, the Shenzhen Institute of Coating Technology was introduced to apply high-spicy peppers to the research and development and production of new special coatings, and after high yield, food processing plants and new special coatings processing plants were put on the ground in Kashgar Economic Development Zone.

　　He Ming predicted that the yield per mu of hot pepper this year would be about 400 kilograms. According to the acquisition agreement signed with Shenzhen and Zhengyuan Science and Technology Group, the income per mu will increase by more than 2,000 yuan this year, which is of great significance for helping local areas consolidate poverty alleviation achievements and rural revitalization.

Hate people, laugh at people.

This is the psychology of many people, although it is a little morbid.

But it does not affect its rapid spread.

After seeing Jia Ling’s "slimming film" YOLO take more than 2 billion box office,

Netizen, you can’t help but spray.

Actually, before the film YOLO was released.

Many netizens said that Jia Ling’s eating was too ugly.

Spend a lot of money on film promotion.

Take "losing 100 pounds" as a gimmick.

Take up too much public resources

But the more fierce netizens scold.

The faster the box office in YOLO rises.

At present, it has opened the gap with the second-ranked Pegasus 2.

There is a simple logic in this.

Any movie that wants to get a high box office.

Everyone needs to work hard on publicity.

Because this is no longer the era of "the fragrance of wine is not afraid of the depth of the alley"

Waiting to drive the box office by word of mouth

The final result will only be several hundred million.

Instead of four or five billion in YOLO.

After the film was released

Douban. com scored 8.0 points for YOLO.

But even so,

There are still many people giving bad reviews to Jia Ling’s new film.

There are various reasons.

It is said that this film is a diet film, and there is no nutrition.

It is said that the plot is extremely poor and consumes women.

There are doubts that the characters in the play are grandiose and unrealistic.

In short, in the eyes of these people

Jia Ling’s new film is a downright bad film.

Shouldn’t get such a high box office

Recently, People’s Daily published a comment on Jia Ling’s new film.

This film is not just about losing weight, but a touching story about loving yourself, bravely pursuing your dreams and persisting.

Anyone who has seen YOLO knows that.

This film is intended to emphasize that people should not be mediocre in their lives.

Seize the opportunity when it comes and work hard for it, even if it fails in the end.

There is nothing to regret.

Perhaps Jia Ling’s new film is flawed in plot design, role positioning and specific plot.

But they can’t hide the light that "Jia Ling lost 100 pounds in order to complete his dream"

The total box office predicted by Cat’s Eye Platform for YOLO is 4.1 billion.

Therefore, there is a saying on the Internet:

Jia Ling lost 100 pounds and earned billions.

With such motivation, everyone can do it.

Don’t say it’s 10 million yuan a catty, it’s 1 million yuan a catty.

There are many people who can do it.

On this ground, they think that Jia Ling is too utilitarian, and at the same time feel that this film has nothing to show off.

In this regard, the old meditation said:

Jia Ling is not a man of god, and she can’t decide the fate of YOLO.

Sometimes, it’s wrong to be results-oriented.

No one can be sure that Jia Ling’s weight loss of 100 pounds will enable YOLO to win billions of box office.

And in the matter of losing weight, Jia Ling’s original intention is to live more comfortably.

Not for the money.

More importantly,

Jia Ling was not poor before filming YOLO.

Don’t expect to make a movie to achieve the goal of turning over or becoming famous overnight.

On the contrary, she is already one of the best hosts in the circle.

And has a strong box office appeal.

Ace to Ace and Travel Notes of Youth Circle are her masterpieces.

Hello Li Huanying made her the highest-grossing female directors in China.

Even if you don’t make a movie and just record a few programs, you will have nothing to worry about in your life.

With this premise.

Jia Ling didn’t meet the film requirements.

Losing 100 pounds crazily is especially valuable.

The current multi-billion box office shows that fans feel the sincerity of Jia Ling.

They are willing to pay for this work of low quality!

Therefore, YOLO is definitely not a simple slimming film, and the value conveyed by the film is more worthy of our deep thinking!

The State Council joint prevention and control mechanism held a press conference on May 31st to introduce the situation of epidemic prevention and control and vaccination. Since May, a total of 50 new confirmed cases have been reported in China, and new confirmed cases or asymptomatic infected people have been reported for 18 consecutive days, involving many provinces.The epidemic situation is characterized by rapid spread and strong spread of strains. The the State Council Joint Prevention and Control Mechanism has sent a working group to Guangdong to guide the handling of the epidemic..What other latest news is worth paying attention to? Let’s look at it together-

How is the national vaccination going?

As of May 30, the country has reported vaccination with Covid-19 vaccine.639.172 million doses. Vaccination has been accelerated on a large scale, with an average of 12.47 million doses per day since May, 2.58 times that of April, with the highest dose per day exceeding 20 million.We should continue to accelerate vaccination and build the Great Wall of Immunization..

How to arrange the recent vaccination work?

From June 10 to 30, the second dose of vaccination was mainly carried out for these target groups who had already received the first dose.However, for those with special needs, such as going abroad and other epidemic prevention and control, continue to inoculate the first dose of vaccine.After July, the first and second doses of vaccination will continue to be fully promoted., do a good job of COVID-19 vaccine inoculation in an orderly manner.

Is COVID-19 vaccine going to be charged?

At present, our vaccination work is based on the needs of epidemic prevention and control in COVID-19, combined with the actual vaccine supply and the vaccination work arrangement at this stage. We advance by steps, highlight key points, and give informed consent.The principle of voluntary and free vaccinationTo vaccinate all kinds of people step by step.Everyone must not believe in rumors, let alone spread them..

Local sporadic cases have appeared in some places one after another. Will the normalization prevention and control measures be adjusted?

Recently, the local epidemics, especially in Guangzhou and Shenzhen, were all caused by the import of foreign viruses.Shenzhen was caused by the mutant virus first discovered in Britain, and the epidemic in Guangzhou was caused by the mutant virus first discovered in India. The spread ability of these two viruses was enhanced than before..

According to this new situation, all the tools in the toolkit for preventing and controlling the spread of epidemic should be called out, and it should be adopted and implemented accurately and forcefully.It may be strengthened and adjusted accordingly in terms of implementation strength, scope and duration..

Any suggestions for the Dragon Boat Festival holiday?

The advice given by holiday activities related to the past has not changed much. It is still that individuals should take precautions. Personal preventive measures include wearing masks in public places, paying attention to personal hand hygiene and respiratory etiquette.

In addition,People in medium-risk and high-risk areas should try to avoid unnecessary travel and reduce the cross-regional spread of the epidemic..

If you have fever or respiratory symptoms during the trip, you should quit the trip in time, avoid contact with other people and seek medical advice in time.Especially to the standardized medical institutions with fever clinics..

Is the domestic COVID-19 vaccine effective for the mutant strain?

We carried out a cross neutralization experiment in China by using the serum obtained from overseas Phase III clinic, including strains found in South Africa and Britain, including epidemic strains found in different regions of China. Up to now, these sera can still react well with these viruses.It should be said that the vaccine still has good protection..

The variation of the virus is eternal, it happens naturally, and at present,As long as the mutation of the virus can be controlled, the vaccine should still be able to protect the current situation for a long time..

Under some special circumstances, enterprises in China are also ready to develop new vaccines in response to sudden major mutations.Vaccines against mutant strains can be developed quickly..

What are the contraindications of Covid-19 vaccine?

Technical Guide to Vaccination in COVID-19 (First Edition)Five situations of vaccination taboo are specified, including:

1. When Covid-19 vaccine or similar vaccine was inoculated before.Have had allergies, this isAn absolute taboo.

2. Previous vaccinationHaving had a severe allergic reaction.

Step 3 suffer fromUncontrolled serious nervous system diseasesYes.

4. beingFeverOr suffer fromAcute diseaseorPatients with acute attack of chronic diseases.

5. Uncontrolled patients with severe chronic diseasesThese are relative taboos.

(The third, fourth and fifth categories are relative taboos. In the course of clinical research, it is not found that vaccination of these groups of people can lead to serious adverse reactions, but it is listed as a taboo for vaccination in order to prevent and guard against it. )

Some taboos, such as fever, acute disease and acute phase of chronic disease, are temporary. When these circumstances leading to taboos no longer exist,You can be vaccinated after recovery and stable disease control..

·Breast-feeding and menstrual women are not taboo for vaccination. Patients with depression, anemia, heart stent, etcIf the drug is well controlled, the condition is stable or you can live a normal life, you can also be vaccinated.

Whether you are taking antiviral drugs and can be vaccinated with Covid-19 vaccine depends on the condition at that time.If you can’t judge yourself, you can consult a clinician to judge whether you can be vaccinated..

What’s the difference between one shot, two shots and three shots?

What we are currently usingInactivated vaccine, adenovirus vector vaccine and recombinant protein vaccine.. These three types have their own characteristics in vaccine composition, production technology, immune principle and immune procedure.

·inactivated vaccineIn the preparation process, the virus is inactivated after a large number of cultures, purified after verification, and then turned into a vaccine. The main feature of this vaccine is that the technology is very mature, it has been used for hundreds of years, and the quality is very stable.Side effects are relatively few., 2 to 8 degrees storage, easy to transport and use.This vaccine is usually given with two injections.The first needle stimulates the immune system to produce memory cells, and the second needle induces a stronger antiviral immune memory response.

·Adenovirus vector vaccineThe S protein of the virus is introduced into adenovirus type 5 vector, and this antigen is introduced into cells by virtue of the ability of adenovirus to enter cells efficiently, and its expression stimulates the immune system. Because of its high efficiency and relative lack of resources,One shot is the whole process of immunity., you can improve the vaccination rate of the whole process of immunization.

·Recombinant protein vaccineIt is to use genetic engineering technology to set up engineering cells to express virus S protein, so that it can be expressed efficiently, and then it will become a vaccine after extraction.In most cases, this vaccine is given three injections, and the best immune response will be obtained after three injections..

These three kinds of vaccines are safe, effective and quality-controllable.The public can safely choose any vaccine for vaccination.

The public must complete the whole process of vaccination and cannot give up halfway.Otherwise, the best protection effect set by the vaccine will not be achieved, that is, preventing virus infection, preventing illness and preventing severe illness.

We can’t relax other public health prevention and control measures when we don’t reach the group immunity barrier among the people.. We haven’t reached the group immunization standard set by the state. After reaching the standard, the country will have corresponding new prevention and control guidelines.

　　When Xiao Hao was three years old, his mother found that his bones became more and more "hard": he couldn’t squat, his arms were difficult to bend, and he was accompanied by hepatosplenomegaly and heart reflux. Sadly, he was never diagnosed … …

　　After six years, Xiao Hao was finally diagnosed — — Suffering from mucopolysaccharide storage type ⅱ, thus, a family knows that there is such a rare disease in the world.

　　May 15th every year is the International Care Day for Mucopolysaccharide Storage. When children have symptoms such as rough face, stunted growth, thick joints, big head, "chicken breast", hepatosplenomegaly, abnormal heart and even mental retardation, they must be careful of Mucopolysaccharide Storage. Mucopolysaccharide, also known as glycosaminoglycan, is a macromolecular substance widely existing in human cells. Mucopolysaccharide is a big family. Your skin is white and tender, your joints are flexible, and your eyes are bright, which is closely related to the members of the "Mucopolysaccharide" family.

　　Although the mucopolysaccharide family is miraculous, there must be a premise that our cells can digest them normally, and the cells have specially prepared a "digestion workshop" — — Lysosome.

　　Lysosomes specialize in degrading foreign or endogenous biological macromolecules, such as lipids, glycogen and mucopolysaccharides, etc., and they can take this big job because of more than 60 enzymes contained in them.

　　More than 60 kinds of enzymes have their own functions, without any one of them, a specific biological macromolecule may not be degraded normally, thus being stored in lysosomes.

　　Lysosomes began to swell, eventually making cells bloated and abnormal, and indigestible macromolecules deposited in various organs of the body, and people’s symptoms became more and more obvious.

　　The reason of enzyme deficiency is often gene mutation. Mucopolysaccharide storage disease (MPS) is a congenital genetic and metabolic disease, which leads to the deposition of this kind of mucopolysaccharides because of the lack of enzymes that decompose the corresponding mucopolysaccharides.

　　According to the different enzymes, mucopolysaccharide storage disease can be divided into seven types and multiple subtypes.

　　Although there are many types, MPS patients have some basic characteristics: multiple organs in the whole body are affected, the development is delayed, and the condition is gradually aggravated; Short stature, rough face, big forehead protrusion, skeletal deformity, thick joints, claw-shaped hands, corneal opacity, otitis media, narrow respiratory tract, hepatosplenomegaly, heart disease, and serious cases will affect intellectual development.

　　There are differences between different types. For example, the majority of patients with type II are men, patients with type III show obvious mental retrogression, and patients with type IV concentrate on skeletal deformity. Similarly, the disease has brought a heavy burden to every patient’s family.

　　Most of the patients with mucopolysaccharide storage disease are children, and they are affectionately called "sticky babies" in China, because the symptoms of MPS are complex and rare, and there may be many undiagnosed MPS patients who are struggling to seek medical treatment in confusion.

　　At first, there was no specific treatment for MPS, and only symptomatic treatment could relieve the pain. In recent years, enzyme replacement therapy has become an effective treatment for some MPS. Simply put, it is "what enzyme is lacking".

　　In recent years, with the country’s increasing attention to rare disease groups, the research and development or introduction of drugs for rare diseases is accelerating. At present, MPSⅣA has become the first MPS therapeutic drug approved for marketing in China. Type I and type II drugs are also expected to be listed in China soon. Type III drugs are still under development; However, as far as the drugs on the market are concerned, they are expensive. Without medical insurance, ordinary families will face an unbearable situation.

　　If we can use specific drugs from an early age, Sticky Baby can enjoy a high-quality life like us. Even if they can’t take medicine, there are still many MPS patients who insist on going to school or work actively, playing their own part.

　　May 15th every year is the International Care Day for Mucopolysaccharidosis. The MPS family in trouble needs everyone’s attention and support. Let’s join these lovely "sticky babies" and hope that the day when medicine can be used will come soon!

　　Medical Guidance: Chief Physician Zhang Huiwen

　　Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine

　　Shanghai Institute of Pediatric Medicine

　　Shanghai Children Rare Disease Treatment Center

　　References:

　　[1] Zhang Huiwen, Wang Yu, Jun Ye, Qiu Wenjuan, Han Lianshu, Gao Xiaolan, Gu Xuefan. Common enzymatic classification of 47 cases of mucopolysaccharide storage disease [J]. Chinese Journal of Pediatrics, 2009,47 (4): 276-280.

　　Shi Huiping. Case diagnosis and prenatal diagnosis of lysosomal storage disease [J]. Chinese Journal of Pediatrics, 1999,37 (1): 57-58.

　　Wu Xiru, Bao Xinhua. Progress in diagnosis and treatment of lysosomal storage disease [J]. Journal of Peking University (Medical Edition), 2005,37 (4): 440-444.

　　Tian Zhiqiang, Ji Shengli. Relationship between glycosaminoglycans and inflammation [J]. Chemistry of Life, 2005,25 (6): 485-487.

　　(Written by Hao Yu, Illustrator/Mai Chuan)

Special feature of 1905 film network Summer file continues to heat up. According to the statistics of ticketing platform, in 2024, the total box office of cinema movies broke 25 billion (including pre-sale). In the summer of 2024, 100 films have been officially finalized. Behind the hundreds of new films are dozens of film companies that are fighting for the front line.

The film was put on file until July 10th. Previously, the cumulative screening and pre-sale box office exceeded 30 million in just three days. As of press time, the cumulative box office has exceeded 40 million, and the number of people watching movies has exceeded one million. The film is also the first work of Bona Film in 2024. Another main production will also be released in July. After a lapse of five years, Bona once again scheduled two main slides for the summer.

Not only that, traditional film companies such as Light Media, Huayi Brothers and Wanda Pictures have also joined the summer file this year, and they are all behind films such as "Safe Evacuation from the 21st Century".

While raising the expectations of the audience, it also leaves suspense for the increasingly hot market: What kind of transcripts will traditional film companies harvest in the summer of 2024?

Development of Summer Files for Traditional Film Enterprises

In the summer of 2024, new films from traditional film companies gathered.

According to statistics, among the hundreds of new films, there are about 20 key films to be shown. Among them, more than half of the films are controlled by traditional film companies such as Bona Film, WANDA CINEMAS, Light Media and Huayi Brothers. According to the data of Cat’s Eye Professional Edition, the number of people who want to see these films has exceeded 10,000, among which the number of people who want to see Legend and White Snake: Floating Life has exceeded 150,000.

As the longest track in the whole year, the summer track has a "youth" that is different from other tracks, and this youth now includes not only students, but also people over the age of 25. According to the report of Lighthouse Research Institute, in recent years, the audience under the age of 25 has shown a downward trend, and the audience aged 25-29 is becoming the main audience in the market. This also makes the appearance of new summer films of traditional film companies more diverse.

This time, Bona Film has a proper emphasis on genre themes and has made some progress in film technology. The Legend, which is under its control, has both a sense of heaviness spanning thousands of years and a sense of lightness of "treasure hunting adventure+fantasy love", and the reconciliation of the two forms the unique epic fantasy temperament of this film. On the other hand, Bona’s A Dream of Red Mansions, which is the main producer, simplifies the complexity and refines the motif of conspiracy and love.

"Legend" restored the 27-year-old young version with the blessing of AI technology, and established the image digital assets of young Jackie Chan. This is also an experimental exploration for the film and television industry. President Bona once mentioned at the Shanghai International Film Festival: "In the past, we often said that movies were the art of regret, but the emergence of AI technology made movies no longer the art of regret."

It seems that it is difficult to find similar films in the whole summer file of "Safe Evacuation from the 21st Century" controlled by Light Media. Judging from the materials released at present, the film is positioned as "comedy+science fiction", with "a sneeze crossing the round trip for 20 years" as the science fiction setting, and at the same time touches the "working mentality" of contemporary young people. The author of the film has a strong style, and the director’s previous works and works also have a rough texture and unconstrained story setting similar to "inferior images". The other "Her Little Pear Vortex" combines a small and fresh campus youth drama with a Northeast comedy, which is suitable for the mainstream audience in the summer file and has a clear audience awareness.

After White Snake 2: The Green Snake Robbed, White Snake: A Floating Life brought the classic story of the White Snake to the screen. According to the director, the film shows the traditional folk customs of the Dragon Boat Festival, such as dragon boat racing and drinking realgar wine. The dragon boat design also refers to the modeling and color matching in the ancient paintings of the Song Dynasty, trying to restore the market atmosphere of the Song Dynasty. This is the first time that Wanda has participated in the series as the main producer. At present, the number of people who want to see White Snake: Floating Life is more than 310,000, ranking among the top five summer movies, and the new domestic film Top1 is to be shown.

In addition, after the equity transfer in WANDA CINEMAS in 2023, Confucianism and Italian Film became its first shareholder, so the films produced by them were regarded as the same sequence. In 2024, "Retrograde Life", which was directed by the owner of Confucianism and Italian Film, was one of the few realistic movies in the summer, and it was also a realistic feature film that was once again the core creation. Judging from the trailers released at present, while focusing on the group of takeout workers, the film does not take bitterness as the background, but incorporates comedy elements with higher acceptance through contrasting situations and actor performances.

Another realistic movie in the summer file is Laifu Hotel, which has been released, and is controlled by Huayi Brothers. The film Douban scored 7.3, which is the highest score among the summer movies that have been released so far. It is also controlled by Huayi Brothers, and it was released in the early summer file and won a focus unit award at Cannes International Film Festival.

Generally speaking, this traditional film company not only pays attention to the younger theme, but also meets the needs of the students, and emphasizes the touch of social reality, the exploration of film technology and the avant-garde image style.

Film and enterprise games show their magical powers

At present, in addition to the new films produced by traditional film companies, there are still many popular films produced and controlled by companies with Internet genes or creative individuals.

For example, the reading group under Tencent and Century Changsheng Tian, the director, are the first and second producers; The Chinese film industry with a mature distribution network and Yitong Film and Television, the director, are the first and second producers. It is the bad monkey film industry and the other film industry as the first and second producers; Most of the films such as Decryption are produced by movie companies with Internet genes such as Cat’s Eye and Taobao Film.

When the online ticketing platform with Internet genes keeps growing in the industry, and when the Mesozoic creators set up their own doors to participate in film investment and film projects, the traditional film enterprises that have grown together with the China film industry for more than 20 years seem to face new challenges.

However, taking the summer file of 2024 as an example, it is not difficult to find that behind most films, several producers jointly invest and share risks. At the same time, there are also traditional film companies behind the films controlled by other film companies, such as WANDA CINEMAS, who is also one of the main producers of Silent Killing. In terms of distribution, traditional film companies also cooperate with other companies to jointly promote the market distribution of films. For example, the distribution of "Retrograde Life" was jointly promoted by Taobao Film, Confucianism, Italian Film and Television, and Sichuan Wenyou.

In addition, the pan-entertainment platform in internet plus, such as Cat’s Eye Lithography, not only has the advantages of Internet technology, but also integrates data resources for reference in upstream production, and can rely on the IP resources and production experience of traditional film companies to complete the upward industrial layout.

The re-integration of resources enables traditional film companies and emerging film companies to better face the uncertainty of the future market. Therefore, while meeting the challenges, win-win cooperation has also become an industry consensus. The complementary advantages in business and the risk-sharing in capital jointly maintain the benign ecology in the industry.

Not only that, as a traditional film company that has been deeply involved in the film industry for decades and contributed many excellent films to the China film market, it has gradually defined a more advantageous track in the competition.

Bona has made it clear in the annual report that he wants to keep the theme projects that the company is good at, including the new mainstream movies. In 2024, Bona held a press conference on the 25th anniversary of "Born to the New" in Shanghai. Apart from Legend and A Dream of Red Mansions, he also announced his main creative lineup, while continuing the creative experience of new mainstream films, and also developed epochal drama works such as Shangganling and Haojiang Tide.

After the successful launch of other animated films and the creation of the domestic animation brand "Striped House", Light Media also regards this field as one of the most promising business sectors. According to the annual report of the enterprise, the series of films has entered the pre-planning stage. Among the new films to be shown, in addition to two highly anticipated animated films "Xiaoqian", the starring actor will also be released this year.

While WANDA CINEMAS continues to deepen its core business such as cinema operation, distribution and marketing, in terms of film investment and production, four of the five films controlled by the main investment last year received positive feedback in terms of box office and word of mouth. In the first half of 2024, Wanda’s "Bears: Reversing Time and Space" made 2.45 billion yuan and 1.99 billion yuan at the box office, respectively, and gained good investment returns. In addition, in the report of the first quarter of 2024, it was also revealed that all the films were filmed and produced as planned.

In a word, no matter new or old, differentiated content is the core competitiveness of a film company. Of course, on this basis, it is equally important for the upstream and downstream industries to cooperate with each other, for different enterprises to give full play to their respective advantages, and to identify the audience characteristics of the schedule.

Hundreds of new films fight for the summer, who can laugh at the end? We will wait and see.